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The MLV liposomes have been developed in many drugs an phospholipid base is made from ceramides, cholesterol, cho lanolin ester, and β-sitosterol, and surfactants are made by using (PEG)nsitosterol(n=5) and K-cetyl phosphate. We made vesicles stable by passing samples through Microfludizer and created multilamellar vesicles to make MLV liposomes similar to the structure of men´s skin. In order to make MLV liposomes, we created lipid membrane films which a mixture of phospholipid base and polyol group was reacted above Tc(95℃) by gelation for 3 hours. As the optimum conditions of Microfluidizer, we figured gut 700 bar for the passing pressure of samples, 40C for its temperature, and 3 times of frequency to pass through samples. Our MLV liposomes is stable on conditions of a low. temperature(5℃) and a high temperature(45℃), which is not to be split in .a large range. We produced our own moisturizing cream"which has a good affinity to skin by means of this system.
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